Cellular Congestion and Insulin Resistance

If the mitochondria gets overwhelmed, it's going to shut down the enzymes that's going to allow things to go into the mitochondria. Then it's going to shut the cell down so you become insulin resistant. And you can become insulin resistant, and then later you can become fatty acid resistant. Now you take somebody to do bloods, and they have high triglycerides, high cholesterol, or high LDL, low HDL, high levels of inflammation, high blood sugar. This is all basically a cell danger response where you probably have too much energy trying to be pushed into the cell because you're too stressed out. So, you know, one of the things that I've been thinking about lately when I look into the biochemistry of it, is it really a caloric toxicity that's causing the issues or is it something deeper? and one of those main regulators is going to be something called acetyl-CoA that's in your mitochondria. When it gets to a level of high, it's going to shut the mitochondria down until I don't, it's going to say I'm overwhelmed. I don't need any more of these substrates. So that's what's going to shut the cell down to stop accepting things. Well, if it shuts that down, then things like glucose and fatty acids are going to get higher in the bloodstream, which can create a level of glucotoxicity and lipotoxicity. Well, where's a really good garbage dump for those things? Fat cells. So we use fat cells as kind of a garbage disposal for excessive things like environmental toxins or like fuel substrates that can't be used initially. And I suppose the outcome of that is things like heading towards type 2 diabetes. Absolutely. Absolutely. Thank you.

This goes back, if we circle around, of why it's so important to get a good level of aerobic fitness and get your VO2 max up. It's especially helpful for people who are getting into that metabolic syndrome, type 2 diabetes type of, if they're moving down the continuum towards that. If I can get someone to do the work and make more mitochondria, it's like they say, many hands make light work. If I have more mitochondria, then I can disperse that excessive amount of fuel to more workers, and I can create more energy out of that. So people, I mean, just looking at that little, because we will see that a fair bit, people coming in who are kind of flirting with type 2 diabetes, kind of on that kind of line of not quite there, but the blood sugar readings are coming in higher than they should be, pre and post-prandial, maybe waking. um you're saying potentially that like if we can like sorry generally the advice that we're getting from the nhs is go and lose weight you know go and lose weight as being the primary kind of um you know thing that's going to have a positive impact and bring the blood sugars down if you lose weight get into a calorie deficit that that's going to be enough um and certainly sometimes we're seeing that other times not necessarily seeing that being enough and And so you're saying potentially this idea of building like an aerobic base is going to be very impactful. That's going to impact massively. Like the NHS isn't wrong. Like one of the best things you can do for your health if you are overweight is to lose body fat. Like that's one of the best things you can do, right? But what are you going to tell the really skinny diabetic about that? When you have a guy who's skinny and he's type two diabetic, what the fuck is he going to lose? He doesn't have any weight to lose. got to build muscle and he's got to build mitochondria right so what you typically see is you see everything is gonna bottleneck out in at certain levels of the biochemistry and everything happens in about the same way but it can happen for different reasons I can be eating and a lot of exogenous food that can be gumming those things up or I can be in a massive calorie deficit my body tanks down my metabolism so now that alters calories and calories out just the same as not doing anything and overeating well so it's two different scenarios but realistically a lot of the same thing happening at the cellular level and then and then every couple kind of extra stresses on top of that shifting people more into that sympathetic nervous system we might be getting that impact of adrenaline on the whole process as well absolutely Absolutely. The lower your HRV is, the more prone you're going to be for having high amounts of adrenaline. The more prone you are to be reactive to things, the more prone you are to anxiety and stress, which is then going to become like a never ending cycle of self induced stress. You know, you've got to that's kind of one of the things you've got to break out of that.